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KMID : 0043320140370060689
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Archives of Pharmacal Research
2014 Volume.37 No. 6 p.689 ~ p.697
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Chemical regulation of signaling pathways to programmed necrosis
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Bae Ji-Hyun
Shim Jung-Hyun
Cho Young-Sik
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Abstract
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Necroptosis is an active and well-orchestrated necrosis, distinctive from apoptosis in microscopic structure, and biochemical and molecular features. Unlike apoptosis-undergoing cells, which are removed by macrophage or neighboring cells, necrotic cell death releases danger signals and provokes inflammation, and further a severe damage to neighbor tissue. A regulated necrosis, termed as necroptosis or programmed necrosis, is emerging as a new paradigm of cell death that can be activated when apoptotic machinery is genetically or pathogenically defective. It plays biological significances in pathogenesis of a variety of inflammatory diseases as well as in a beneficial innate immune defense mechanism. This review highlights the identification of hits against necroptosis, and comprehensive approaches to discovery of small molecules that regulate necroptotic cell death. Also, the signaling molecular mechanism of necroptosis and future clinical uses of necroptosis inhibitor will be described in brief.
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KEYWORD
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Programmed necrosis, Necroptosis, Small molecules, Regulation, Signaling pathway
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